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The Hippocratean categories later came to be used to define almost everything: seasons, periods of the day, the principal elements, Zodiacal signs, tastes, ways of thinking, basic characteristics, stages of human life, or branches of art. Thinking in types soon became an obvious option in art too, and colours provided the means to achieve it.

Red, black, yellow, and white were associated with bodily humours, and the mixture of colours in the image was thought to reflect temperaments. The most apparent and direct adoption of the Hippocratean system in art is in Durers 1526 painting, the Four Apostles.