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It remains unclear whether the 1,2,3-triazolyl ring, which enters the p -position of the phenyl group in UNI by a click reaction 27, of Abz-E2B is required for the selective inhibition of CYP707A. Additionally, the click chemistry requires three steps (amination, azidation and click reaction), which was the leading cause of the low synthetic yield of Abz-E2B.
This should decrease the log P value to less than 4. 00, increasing the water solubility 22.