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We finish by depicting some estimation procedures and approximations, and conclude with discussion and recommendations. A (part of such) clot can break off and be carried through the bloodstream to the lungs and there cause a blockage (pulmonary embolism), preventing oxygenation of the blood and potentially causing death. The diagnosis DVT presence or absence can (ultimately) be made using repeated leg ultrasound, which requires patient referral and is to some extent burdening and time and money consuming.

Hence, it is desirable to predict the presence or absence of DVT without having to refer patients for more cumbersome testing, by rather using easy to obtain predictors from their patient history, physical examination and simple blood assays. In this article, we use these data to illustrate the described meta-analysis methods for identifying important risk factors.